Computer intelligence spots genes linked to Duchenne Muscular Dystrophy

Thursday, March 16, 2017

Using computational intelligence, researchers have identified a set of genes that are "collectively responsible" for Duchenne Muscular Dystrophy (DMD), a genetic disease causing progressive decay in muscles.

Surama Biswas and Sriyankar Acharyya, both from the Department of Computer Science and Engineering, Maulana Abul Kalam Azad University of Technology, West Bengal, mined a dataset of around 50,000 genes to obtain a sub-set containing 30 genes.

"The sub-set containing 30 genes are collectively discriminant in gene expression between DMD affected patients and normal persons. This means that although these genes are present in both affected and normal people, the way the instructions encoded in these genes are used to synthesise gene products (usually proteins), are different in the two categories of people," Biswas told IANS on Thursday.

The genes identified may be clinically investigated to design new drugs and/or modify existing drugs for DMD, Biswas said.

To hunt for the genes in a reasonable amount of time, two algorithms were devised based on existing meta-heuristic algorithms.

Meta-heuristic aims to find good or near-optimal solutions at a reasonable computational cost and time.

DMD affects about one in 5,000 males at birth. It is the most common type of muscular dystrophy. Lack of or defect in muscle cell structural proteins is the basic cause of muscular dystrophy.

Although a gene called DMD has previously been identified, Biswas said the disease is triggered by a collection of all the genes.

Explaining their motivation for the study, Biswas said: "DMD may affect a boy of the age group 3-5 years. DMD initially affects the muscles of limbs causing gradual decay and hampers mobility. Finally it harms the muscles of major organs which leads to death. Application of computational intelligence / soft computing in healthcare of women and kids is the thrust area of our research group."

"Shortage/unavailability of data is always a limitation for computational research. More methods and datasets may always be employed for validating the research," Biswas added.

The study is available in Springer's Computer Society of India (CSI) transactions on ICT (information and communication technology) journal for March issue (volume 5).


Express your comment on this article

Submit your comments...
     
Disclaimer: The views expressed here are strictly personal and IndiansinKuwait.com does not hold any responsibility on them. We shall endeavour to upload/publish as many of the comments that are submitted as possible within a reasonable span of time, but we do not guarantee that all comments that are submitted will be uploaded/published. Messages that harass, abuse or threaten other members; have obscene, unlawful, defamatory, libellous, hateful, or otherwise objectionable content; or have spam, commercial or advertising content or links are liable to be removed by the editors. We also reserve the right to edit the comments that do get published. Please do not post any private information unless you want it to be available publicly.
Image

India - Global host of 2018 World Environment Day

India is the global host of 2018 World Environment Day which is taking place on June 5, 2018. The t

Image

Students should proactively indulge in co-curricular activities - Raghavi Vishwanath an alumni of FAIPS Kuwait

When youngsters reach a pinnacle it is always a pleasure to learn more about their lives and how th

Image

A thought for Ramadan

Sunday, the 13th of May, 2018 Festival greetings, Happy Sunday greetings Mother’s Day greetings

Image

Kuwait Cricket - A Sense of accomplishment: Herschelle Gibbs

In the recently concluded ICC World Twenty20 Asia Qualifiers ‘A’ , the Kuwait's national crick

Image

Raindrops - Usual and Unusual Stories of love by Dr. Navniit Gandhi

Dear Readers, Dr Navniit Gandhi has penned a collection of 19 true, usual and a little unusu

Image

Love is in air when he sings, Shahbaz Aman

What could be the appropriate adjective to describe this man; singer; composer; or an unusual embod

Image

Don’t Want a Day… Want a Deal!

I am a Woman and like me, there are countless other women out there who do not want Days to commemo

Image

My heart, my soul and all my sincerity is for this country – Ajiaz Ahmad Sarfaraz

“By serving this great country for more than three decades, I feel that the word ‘great’ fully appl

Image

Teamwork Makes The Dream Work! – Nomaan Sidiq Budroo, Captain of Kuwait U-19 Cricket Team

Kuwait Cricket’s National U 19 team returned home after their best ever performance in the ICC U 19

Image

A Walk in the Garden…

Our garden in Salmiya is an exciting learning-place… Every walk in it, teaches something every time

Image

True sense of Indian luxury at Asha’s Restaurant

Who doesn’t like a luxurious dine out once in a while with families and friends? What if it is coup

Image

Zafran Indian Bistro with innovative Indian Cuisines

Indian Cuisines are packed with interesting ingredients and enticing aromas that make it super deli

Image

New Menu at Zafran Puts Contemporary Spin on the Traditional

Fans of Zafran can rejoice as the popular Indian bistro launches a new menu this week. The front

Image

A nostalgic and delicious train journey in Kuwait at Kerala Express Restaurant

A train journey during our annual vacation in India is definitely a nostalgic experience for many o

Image

22 Yards Cricket Academy Summer Camp For Cricket Coaching

22 Yards Cricket Academy, a professionally run Cricket coaching center having its 16th year of succ

Image

KCWA organized ‘Play on Indoor Sports’

Kuwait Canara Welfare Association (KCWA), for the first time organized an Indoor “Play on Sports” e

Image

Don Bosco Oratory (DBO) Beat Kuwait Independents Hockey (KIH) 1/0 in The First 2018 DBO Hockey Tourunament

Kuwait, Ahmadi – 12 May 2018, in what would one say “breathless showpiece” DBO and KIH. It was anot

Image

Kuwait Cricket set to host ICC World Twenty20 Asia Qualifier ‘A’

Whilst this is not the first International tournament to be hosted in Kuwait, this particular editi

Image

Himanta Biswa Sarma elected BAI President

Assam Health and Education Minister Himanta Biswa Sarma was on Tuesday unanimously elected the Badm